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These conclusions placement EBNA-3a comparable to a vital modulator of B mobile proliferation and survival by EBV latency, and as becoming a appropriate CD8⁺ T cell reason in The two basic immunological experiments and translational examine.
This peptide pool is an ideal Device for: Characterizing client-precise or vaccine-induced T cell responses
Along with that, adoptive T mobile therapies like posoleucel also aim LMP2 along with other latency proteins for example EBNA1, reinforcing its significance as becoming a conserved and immunodominant antigen.
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EBNA-3a seems to regulate a subset of cellular genes, a number of which overlap with Those people regulated by EBNA2. The 2 proteins can act antagonistically or cooperatively to manage gene expression. These findings placement EBNA-3a as a essential modulator of B mobile proliferation and survival in the course of EBV latency, and as a related CD8⁺ T cell focus on in the two simple immunological studies and translational analysis.
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